As the daughter of Thanos and arguably the strongest character on the Guardians of the Galaxy team, Zoe Saldana has flexed her muscles in many scenes. Unfortunately, as Hello Magazine states, these same muscles have caused her pain in her everyday life, as Saldana suffers from Hashimoto’s thyroiditis. The disorder causes her immune system to turn against her own body, leading to symptoms such as muscle pain and fatigue. Saldana talked about how she feels at times as a result of the disorder: “Your body doesn’t have the energy it needs to filter toxins, causing it to believe that it has an infection, so it’s always inflamed.”

According to WebMD, the actress knew from a young age that she could develop Hashimoto’s thyroiditis during her life. Her mother and two sisters also suffer from the disorder, and Saldana herself began to show the early signs at 17 years old. The actress recalled her mother facing the illness during her childhood, saying, “My mother struggled with Hashimoto’s early on in her life — fighting fatigue, wanting to live a more active life, constantly feeling like her body was inflamed — and we were already showing markers for it from bloodwork [we had done] as teenagers.”

Hashimoto’s often leads to hypothyroidism, a disorder with symptoms including fatigue, weight gain, and memory problems. As a result, Saldana altered her eating habits and does not consume diary or gluten.

As Shuri, the younger sister of T’Challa and technological genius of Wakanda, Letitia Wright bought a humorous sarcasm to the role and made the character a fan favorite. Her performance garnered critical praise and awards, including a 2019 BAFTA for “Rising Star.” According to Insider, Wright used her acceptance speech to reveal the personal struggles she’d faced with depression and how she had been ready to give up on acting.

Wright credits much of her success and ability to pull out of her depressed state to her faith, family, and the British Academy of Film and Television Arts, stating during the speech, “The only thing that pretty much pulled me out of that was God, my belief, my faith, my family, and an email from BAFTA saying that they wanted me to be a part of the BAFTA Breakthrough Brits, and I was like ‘let me try again.'”

During her press tour for Black Panther, Wright used her platform and her own personal experience in order to change the narrative of mental health in the Black community, as told by USA Today: “In the Black community, it’s something that happens, but we don’t speak about it. We have to continue to talk about it and bring it straight to the forefront.”

Rotten Tomatoes reports that with the death of Chadwick Boseman and the studio having no plans to recast for the role of T’Challa, future installments of the Black Panther franchise will focus more on Wright’s character Shuri.

Mark Ruffalo’s journey in the MCU began at the front of the line, making his first appearance as Dr. Bruce Banner, aka the Hulk, in The Avengers, having taken over the role from Edward Norton. Still, Ruffalo’s portrayal of the doctor trying to control his emotions before embracing the powerful green monster became as loved as anyone else in the ensemble cast. In December 2008, the actor lost his younger brother, Scott Ruffalo, to a murder that remains unsolved, according to the Huffington Post.

According to Reuters, the case originally had two persons of interest. Brian Scofield and his girlfriend at the time, Shaha Mishaal Adham, both turned themselves in but were eventually released. Adham claimed that the death was not a murder but the result of a game of Russian Roulette gone wrong, as reported by Medium. Her lawyer claimed that Scott Ruffalo had been a known cocaine user (Scott was convicted in April 2002 for possession of a controlled substance for sale) and had often toyed with firearms in the past, leading the Beverly Hills Police Department to proclaim Scott’s death a suicide. However, physical evidence indicated suicide was impossible, and his death was re-labeled as a homicide.

ABC News reports that between 1991 and 2001, Scott held a cosmetology license and set up his own studio, Ruff Inc., which took in massive profits from high-class clients with locations in Santa Monica and Beverly Hills. In 2012, Adham died of a drug overdose, and to this day, Scott’s murder remains unsolved.

Agent Phil Coulson was Nick Fury’s right-hand man and helped him recruit the heroes for the Avengers before spinning off in his own cable series. His actor, Clark Gregg, went through quite lot to get to that point.

In a 2016 interview with Marc Maron, Gregg described himself as having been a functional alcoholic and stated that he regularly used drugs and alcohol before launching his career as an actor. In fact, he admitted that it was “a miracle” he was able to become an actor, as he regularly abused substances for more than a decade.

Gregg overcame his struggles with substance abuse and became a successful actor within the MCU. However, he soon found himself faced with another issue. In a 2018 feature in Men’s Health, Clark admitted to having suffered anxiety and panic attacks during his acting career. He recalled a moment when he was sitting in what was supposed to be a relaxing vacation spot with his family but felt “as uncomfortable as you can possibly be in your own skin.” Gregg described panic attacks that came without the common symptoms one would expect before them, as well as the anxiety that followed after these attacks. Only after beginning cognitive behavior therapy did he begin to see a change in himself. Like his career, Clark Gregg refers to the therapy as “a miracle.”

Deadpool might not have started out as an MCU character, but, as reported by Collider, Deadpool 3 will, in fact, be an MCU film. The previous two movies were packed with impressive stunt work, yet, tragically, according to BBC News, a failure to implement proper safety measures led to the death of a stuntperson on the set of Deadpool 2.

Joi Harris was a 40-year-old motorcycle road racer and stuntwoman who used her platform to push for more women of color in road racing, as told by People. Harris marketed herself as “the first licensed African American woman in U.S. history to actively compete in sanctioned motorcycle road racing events.” In 2017, she worked as the double for Zazie Beatz’s character, Domino, in Deadpool 2. However, during a stunt on a motorcycle, Harris suffered a fatal crash.

According to The Wrap, the stunt involved Harris driving a motorcycle down a ramp on a flight of stairs. She lost control and collided with a building. An investigation following the incident by WorkSafe BC said that 20th Century Fox had violated multiple safety rules, such as setting up a barrier to protect her from hitting the building and not allowing her to wear a safety helmet. Harris also was not given an orientation, despite the film being her first job as a stuntperson. Global News reports that a Vancouver-based production company was fined approximately $300,000 for these failures.